CareerPlanSign in

Machine Learning Engineer

San Francisco💼 Full-time🗓 2026-09-03 → 2026-09-29

Core

Build machine-learning systems to remove bottlenecks in drug discovery and development, bridging research and engineering to accelerate experiments and decision quality.

Role type

Senior IC machine-learning engineer (biomolecular modeling & drug discovery)

Builds

Systems for experiment planning, literature triage, protocol drafting, in silico screening, candidate generation, filtering, predictive analysis, and active-learning loops connecting predictions to wet-lab results.

Domain

Biopharma / Drug Discovery / Biomolecular Modeling

Deliverable

production ML models

Required skills

Strong research judgment in biomolecular modeling, ability to own ambiguous problems end-to-end, practical interest in wet-lab constraints, experience with active learning, data-constrained biological modeling, multimodal omics, imaging, or phenotypic data

Preferred skills

Experience with production-scale agent platforms

Technologies

ESM, AlphaFold-family models, RFdiffusion, ProteinMPNN, molecular dynamics, post-training, probing, evaluation

Responsibilities

Identify high-value bottlenecks in drug discovery where ML can improve speed or decision quality; Build systems for experiment planning, literature triage, protocol drafting, in silico screening, candidate generation, filtering, and predictive analysis; Fine-tune and apply biomolecular models (ESM, AlphaFold, RFdiffusion, ProteinMPNN) using company data; Develop candidate-analysis workflows including molecular dynamics and evaluation; Work directly with wet-lab scientists to automate preclinical/clinical workflows; Create internal evaluations measuring model impact on experimental throughput and candidate quality

Seniority

Senior, hands-on IC

Sourced via ashby · Listed on CareerPlan, which tracks 853,000+ jobs from 20+ sources.