Principal Software Engineer
Core
Own technical design and architecture for the Variant Knowledge Platform, defining data models and API contracts for variant identity, classification, and annotation to power clinical interpretation and analytics.
Role type
Principal Software Engineer (Backend/Platform)
Builds
Production-grade REST APIs, data pipelines, and multi-tenant systems for genomic variant data.
Domain
Healthcare / Genomics / Bioinformatics
Deliverable
production ML models
Required skills
REST API design, data modeling, cloud architecture, backend programming, technical leadership, system architecture, data migration
Preferred skills
Genomics/bioinformatics, event-driven architectures, regulated environment experience, multi-tenant platform design, distributed systems
Technologies
AWS, Okta, Python, Snowflake, REST, SQS
Responsibilities
Define and evolve data models for variant identity and classification; Design production-grade, versioned REST API contracts; Lead evolution of systems turning raw bioinformatic data into trustworthy variant information; Drive architecture for automating evidence placement and scaling data storage; Mentor engineers across multiple teams; Partner with cross-functional stakeholders to align technical strategy with business opportunities.
Seniority
Principal, hands-on IC with org-wide leadership
