Principal Scientist, Pharmacology
Core
Lead molecular biology strategy and execution for pharmacokinetics, pharmacodynamics, biodistribution, and target engagement studies of RNA therapeutic candidates.
Role type
Principal Scientist, Pharmacology (hands-on IC)
Builds
RNA therapeutic development programs
Domain
Biotechnology / RNA therapeutics / Pharmacology
Required skills
quantitative molecular biology, assay development, complex biological sample analysis, experimental design, data integration, SOP creation, cross-functional coordination, scientific presentation
Preferred skills
RNA therapeutic development experience, preclinical pharmacology data preparation, regulatory interaction experience
Technologies
RT-qPCR, qPCR, ddPCR, RNA/DNA extraction, cDNA synthesis
Responsibilities
Design and lead quantitative molecular biology studies; Develop and optimize molecular assays; Establish sample-processing workflows; Analyze complex datasets; Lead troubleshooting and root-cause investigations; Establish and maintain SOPs; Coordinate cross-functionally; Present data to guide program decisions
Seniority
Principal, hands-on IC with mentorship