Group Leader, Antibody-Oligonucleotide Conjugates (Extrahepatic Delivery)
Core
Lead an interdisciplinary team developing antibody-oligonucleotide conjugates (AOCs) for extrahepatic delivery, integrating antibody discovery, linker chemistry, and bioanalytical validation.
Role type
Senior Group Leader, Antibody-Oligonucleotide Conjugates (AOCs)
Builds
AOC assets for extrahepatic tissue targeting (e.g., muscle, adipose, immune cells) advancing from discovery to clinical development.
Domain
Biotechnology / Nucleic Acid Therapeutics / Protein Engineering
Required skills
Antibody discovery and engineering, Bioconjugation chemistry, Linker design, Analytical characterization (LC-MS, SEC, CE-SDS), In vitro/in vivo assay development, Team leadership, CRO management, IP strategy
Preferred skills
Experience with ADCs or related conjugate modalities, Computational antibody design, Scale-up readiness (CMC), Patent filing experience
Technologies
Phage/yeast display, Hybridoma, Click chemistry, Enzymatic conjugation, Flow cytometry, Microscopy, qPCR, NGS, LC-MS, SEC, CE-SDS, HIC
Responsibilities
Define AOC design principles for extrahepatic delivery; Oversee generation and engineering of antibodies for specific tissue targeting; Own bioconjugation strategy and linker optimization; Develop functional validation readouts (binding, internalization, PK/PD); Lead cross-functional partnerships with DMPK, Bioanalytics, and CMC; Recruit, mentor, and build a scientific team.
Seniority
Principal Scientist / Group Leader
