Scientist I/II - Cardiovascular & Metabolic Diseases Pharmacology
Core
Design, execute, and analyze integrated in vitro and in vivo pharmacology studies for oligonucleotide discovery programs targeting obesity and MASH.
Role type
Senior IC pharmacologist (translational)
Builds
Decision-enabling data for RNA-based drug and vaccine development
Domain
Biopharma / Nucleic Acid Therapeutics
Required skills
in vitro and in vivo study design, ASO/siRNA transfection, metabolic cell culture, rodent PK/PD studies, molecular biology (RT-qPCR, Western blot), statistical analysis, IACUC protocol management
Preferred skills
metabolic disease pharmacology expertise, RNA therapeutics experience
Technologies
GraphPad Prism, Excel, ImageJ, Seahorse XF, Oil Red O, BODIPY
Responsibilities
Design and execute integrated in vitro and in vivo studies; Perform ASO and siRNA transfection and dose-response experiments; Culture and maintain metabolic cell models (hepatocytes, myotubes, adipocytes); Develop and manage IACUC protocols for rodent studies; Execute efficacy and PK/PD studies in mouse models; Analyze data and prepare scientific reports
Seniority
Senior, hands-on IC