Senior Scientist or Principal Scientist, Targeted Proteomics

Watertown, MA💼 Full-time💰 $115,000–$115,000🗓 2026-07-31 → 2026-10-01

Core

Lead targeted proteomics strategies and assay development to support drug discovery and clinical-stage decision-making for targeted protein degradation (TPD) medicines.

Role type

Senior Scientist / Principal Scientist, Targeted Proteomics

Builds

Pharmacodynamic profiles and quantitative protein data for preclinical and clinical studies

Domain

Biotechnology / Targeted Protein Degradation / Mass Spectrometry

Required skills

targeted proteomics strategy, PRM/MRM assay development, immunoaffinity enrichment, LC-MS instrumentation operation, Skyline data analysis, CRO management, regulatory documentation

Preferred skills

cross-functional drug discovery leadership, complex scientific communication, regulatory compliance experience

Technologies

nano-LC, Orbitrap MS, Skyline, DDA, DIA

Responsibilities

Define scientific questions addressed by targeted proteomics; develop and optimize targeted protein mass spectrometry assays; generate pharmacodynamic profiles across biological matrices; lead proteomics activities at CRO partners; present strategic recommendations to leadership.

Seniority

Senior, hands-on IC

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About kymera therapeutics

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.