Scientist II, Degrader Antibody Conjugate Characterization
Core
Lead the development of analytical workflows for Degrader Antibody Conjugate (DAC) platforms, designing assays and defining quality criteria to advance novel therapeutic candidates.
Role type
Senior IC analytical scientist (ADC/DAC characterization)
Builds
High-throughput DAC screening platforms and quality assessment frameworks
Domain
Biopharmaceuticals / Targeted protein degradation
Required skills
ADC/DAC characterization, LCMS, HPLC, method development, assay design, data interpretation, troubleshooting, project management
Preferred skills
Native LCMS, positional isomer analysis, glycan analysis, CE-SDS, peptide mapping, biophysical binding assays, thermal stability, developability assessment, Agilent instrumentation
Technologies
LCMS, HPLC, SEC, HIC, MassHunter, Byos
Responsibilities
Design and execute DAC screening characterization including DAR, aggregation, and protein quantitation; Lead in-depth characterization of antibodies and advanced DACs including isomers and stability; Integrate analytical data into unified assessments to drive go/no-go decisions; Develop and optimize LCMS/HPLC methods for throughput and robustness; Collaborate with chemistry and bioanalytical teams to align workflows and influence advancement decisions
Seniority
Senior, hands-on IC
