Principal Scientist - Cardiometabolic Disorders
Core
Provide scientific leadership for the discovery and preclinical development of next-generation therapeutics for obesity and related cardiometabolic diseases.
Role type
Principal Scientist (Drug Discovery, Preclinical)
Builds
Innovative therapeutic candidates for obesity and cardiometabolic diseases
Domain
Biotechnology / Pharmacology / Cardiometabolic Disorders
Required skills
Translational pharmacology strategy, in vitro/in vivo study design, GPCR biology, pharmacological characterization of biologics, data integration for decision making, scientific leadership, mentoring
Preferred skills
GPCR-based assay development, peptide/antibody therapeutic expertise, mechanism-of-action studies, cross-functional collaboration, scientific publication
Technologies
GPCR-targeted drug discovery platforms, functional signaling assays, ligand-binding assays, β-arrestin assays, cAMP/calcium mobilization assays
Responsibilities
Lead target identification and validation through candidate selection; Design and interpret in vitro and in vivo pharmacology studies; Mentor scientists and lead cross-functional teams; Present findings to senior leadership and external audiences; Contribute to scientific strategy and publications
Seniority
Principal, hands-on IC with strategic leadership