Principal Scientist
Core
Lead antibody engineering initiatives to design, execute, and interpret experiments for next-generation recombinant antibody therapeutics.
Role type
Principal Scientist (Antibody Engineering)
Builds
Next-generation recombinant antibody therapeutics
Domain
Biopharmaceuticals / Protein Engineering
Deliverable
production ML models | product features
Required skills
Antibody engineering (design, expression, purification, characterization), SPR/BLI, ELISA, flow cytometry, protein interaction assays, experimental design, scientific leadership, data analysis, technical documentation
Preferred skills
Antibody-drug conjugates, multispecific formats, bioinformatics, physics-based protein modeling, AI/ML-enabled discovery tools, X-ray crystallography, cryo-EM, isothermal titration calorimetry, multi-angle light scattering, oncology/immunology/neuroscience therapeutic areas
Technologies
SEC, SPR, BLI, ELISA, flow cytometry, AI/ML tools, X-ray crystallography, cryo-EM, ITC, MALS
Responsibilities
Design and execute antibody engineering workflows (affinity maturation, humanization, format conversion); Engineer and evaluate various antibody formats (IgG, Fab, scFv, bispecific, multispecific); Characterize antibodies using biophysical assays; Partner across multidisciplinary teams; Analyze complex datasets to identify risks; Evaluate and implement emerging technologies including AI/ML; Lead scientific discussions and present findings; Author protocols and technical documentation for regulatory submission
Seniority
Principal, hands-on IC with strategic leadership