Principal Scientist I/II, Oligonucleotide Chemistry & Innovation
Core
Lead the development of novel oligonucleotide chemistries and conjugates to advance RNA therapeutics from discovery through preclinical stages.
Role type
Principal Scientist, Oligonucleotide Chemistry & Innovation
Builds
Novel oligonucleotide chemistries, conjugates, and preclinical RNA therapeutic candidates
Domain
Biopharmaceuticals / RNA Therapeutics / Chemical Synthesis
Required skills
Solid-phase oligonucleotide synthesis, deprotection, purification, characterization, phosphoramidite chemistry, automated synthesizer operation, analytical instrumentation (HPLC, LC-MS), RNA therapeutics knowledge (siRNA, ASO)
Preferred skills
Structure-activity relationship studies, cross-functional collaboration, laboratory workflow optimization, SOP development
Technologies
HPLC, LC-MS, automated oligonucleotide synthesizers
Responsibilities
Lead synthesis, purification, characterization, and analysis of chemically modified oligonucleotides; Design and optimize novel oligonucleotide chemistries; Develop robust synthetic routes for preclinical candidates; Mentor scientists and enhance laboratory workflows; Establish standard operating procedures for manufacturing processes; Operate and maintain critical analytical and synthesis instrumentation
Seniority
Principal, hands-on IC with mentorship