Vertex Spring Co-Op 2027, Process Development
Core
Establish a cryo-microscopy workflow to evaluate cryoprotective agent diffusion into islets and characterize islet responses for Type 1 Diabetes drug product development.
Role type
Co-op process development scientist (cell therapy/cryopreservation)
Builds
Cryopreservation processes for stem cell-derived islet therapies
Domain
Biopharmaceuticals / Cell and Gene Therapy
Required skills
mammalian cell culture, aseptic technique, stem cell handling, cell cryopreservation, cell microscopy, image acquisition, image-based evaluation, computational modeling (molecular dynamics/diffusion kinetics), experimental design, data analysis
Preferred skills
experience with cell aggregates/spheroids/organoids, cryo-microscopy experience, 3D cell systems
Technologies
cryo-microscopy, electronic laboratory notebooks (ELNs)
Responsibilities
Establish standardized cryo-microscopy workflow for real-time imaging of stem cell-derived islets; Design and execute cryopreservation studies using selected CPA formulations; Develop initial computational modeling framework to correlate CPA diffusion kinetics with islet morphology; Integrate experimental and computational results to characterize CPA diffusion kinetics and inform formulation optimization; Maintain detailed records in ELNs and author study reports/protocols
Seniority
Co-op (graduate student level)
